SAFETY OF UVARIA CHAMAE P. BEAUV ROOTS AQUEOUS EXTRACTS IN WISTAR RATS

Uvaria chamae is used in the treatment of sickle cell crisis Benin. The aim this work to determine safety roots aqueous extract wistar rats. was obtained by maceration. tests for Acute Oral Toxicity (AOT) and Sub-Chronic (SCT) respectively forced gavage a single dose 2000 mg / Kg 200 body weight 28 days were performed on female Wistar animals, serum creatinine, transaminases number white blood cells determined day 0 then 14 AOT SCT. Histologic analysis liver, kidneys spleen both tests. There no deaths toxicity testing organ histology did not show atypia. Weight, AST ALT transaminases, mean count change significantly between start end experiment Only creatinine decreased SCT, indicating more protection kidney function. hepatic, renal immune acute or sub-chronic state.